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Celecoxib is a white to off-white powder with a pKa of 11.1sulfonamide moietyCelecoxib is hydrophobiclog P is 3.5and is practically insoluble in aqueous media at physiological pH range.
Liver and biliaryHepatic enzyme increasedincluding SGOT increasedSGPT increased)
Taking Celebrex during the last 3 months of pregnancy may harm the unborn babyTell your doctor if you are pregnant or plan to become pregnant while using Celebrex.
Observational studies conducted in the Danish National Registry have demonstrated that patients treated with NSAIDs in the post-MI period were at increased risk of reinfarctionCV-related deathand all-cause mortality beginning in the first week of treatmentIn this same cohortthe incidence of death in the first year post-MI was 20 per 100 person years in NSAID-treated patients compared to 12 per 100 person years in non-NSAID exposed patientsAlthough the absolute rate of death declined somewhat after the first year post-MIthe increased relative risk of death in NSAID users persisted over at least the next four years of follow-up.
In patients who are known or suspected to be poor CYP2C9 metabolizersi.eCYP2C9*33based on genotype or previous history/experience with other CYP2C9 substratessuch as warfarinphenytoinadminister CELEBREX starting with half the lowest recommended doseAlternative management should be considered in JRA patients identified to be CYP2C9 poor metabolizerssee DOSAGE AND ADMINISTRATION and CLINICAL PHARMACOLOGY
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