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Coadministration may cause serotonin syndrome Do not use concomitantly or initiate bupropion within 14 days of stopping an MAOI Converselyat least 14 days should be allowed after stopping bupropion before starting an MAOI antidepressant Starting bupropion in a patient who is being treated with linezolid or IV methylene blue is contraindicated because of an increased risk of serotonin syndrome If linezolid or IV methylene blue must be administereddiscontinue bupropion immediately and monitor for CNS toxicitymay resume 24 hr after last linezolid or methylene blue dose or after 2 weeks of monitoringwhichever comes first.

Begin therapy 1 week before target quit dateusually second week of treatmentMay be used in combination with nicotine patch.

Your health care provider will want to see you often while you are taking bupropionespecially at the beginning of your treatmentBe sure to keep all appointments or office visits with your doctor.

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