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Co-administration of the following drugs with ketoconazole is contraindicateddofetilidequinidinepimozidecisaprideKetoconazole can cause elevated plasma concentrations of these drugs and may prolong QT intervalssometimes resulting in life-threatening ventricular dysrhythmias such as torsades de pointesSee CONTRAINDICATIONSWARNINGSand PRECAUTIONSDRUG INTERACTIONS sections.
Patients should be instructed to report any signs and symptoms which may suggest liver dysfunction so that appropriate biochemical testing can be doneSuch signs and symptoms may include unusual fatigueanorexianausea and/or vomitingabdominal painjaundicedark urine or pale stoolssee WARNINGS section
Oral imidazole compounds such as ketoconazole may enhance the anticoagulant effect of coumarin-like drugsthus the anticoagulant effect should be carefully titrated and monitored.
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