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Taking MAO inhibitors with this medication may cause a seriouspossibly fataldrug interactionAvoid taking MAO inhibitorsisocarboxazidlinezolidmethylene bluemoclobemidephenelzineprocarbazinerasagilinesafinamideselegilinetranylcypromineduring treatment with this medicationMost MAO inhibitors should also not be taken for two weeks before and after treatment with this medicationAsk your doctor when to start or stop taking this medication.

Do not use Zyban if you have used an MAO inhibitor in the past 14 daysA dangerous drug interaction could occurMAO inhibitors include isocarboxazidlinezolidmethylene blue injectionphenelzinerasagilineselegilinetranylcypromineand others.

Similarlyefavirenz 600 mg once daily for two weeks reduced the exposure of bupropion by approximately 55in healthy volunteers.

If necessarythis medication may be combined with nicotine patches or gum to help you quit smokingAsk your doctor for more informationThe combination of nicotine and this medication may increase your blood pressureYour doctor may need to monitor your blood pressure closelyDo not smoke at any time if using any nicotine products with this drugToo much nicotine can cause serious side effects.

Some epidemiological studies of pregnancy outcomes following maternal exposure to bupropion in the first trimester have reported an association with increased risk of certain congenital cardiovascular malformations specifically ventricular septal defects and left outflow tract heart defectsThese findings are not consistent across studiesAnimal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicitysee section 5.3Zyban should not be used in pregnancyPregnant women should be encouraged to quit smoking without the use of pharmacotherapy.

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