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Discontinu mtomin at th tim ban iodinatd contast imaging pocdu in patints with an G btwn 30-60 mL/minut/1.73 m?; in patints with a histoy liv disas, alcoholism, hat ailu; in patints whwill b administd inta-atial iodinat contast valuat G 48 h at th imaging pocdu; stat mtomin i nal unction is stabl.

ACTOPLUS MT may b titatd up ta maximum daily dos 45 mg pioglitazon and 2550 mg mtomin.

Tumos w obsvd in th uinay bladd mal ats in th two-ya cacinognicity study [s Nonclinical Toxicology ]. In tw3-ya tials in which pioglitazon was compad tplacbglybuid, th w 16/3656 (0.44%) pots bladd canc in patints taking pioglitazon compad t5/3679 (0.14%) in patints not taking pioglitazon. At xcluding patints in whom xposu tstudy dug was lss than on ya at th tim diagnosis bladd canc, th w six (0.16%) cass on pioglitazon and tw(0.05%) cass on placbo.

Thiazolidindions, including pioglitazon, which is a componnt ACTOPLUS MT, caus xacbat congstiv hat ailu in som patints [s WANINGS AND PCAUTIONS]. At initiation ACTOPLUS MT, and at dos incass, monitpatints caully signs and symptoms hat ailu (.g., xcssiv, apid wight gain, dyspna, and/dma). I hat ailu dvlops, it should b managd accoding tcunt standads ca and discontinuation dos duction ACTOPLUS MT must b considd [s WANINGS AND PCAUTIONS]. ACTOPLUS MT is not commndd in patints with symptomatic hat ailu. Initiation ACTOPLUS MT in patints with stablishd Nw Yok Hat Association (NYHA) Class III IV hat ailu is containdicatd [s CONTAINDICATIONS and WANINGS AND PCAUTIONS].

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