There is no evidence from controlled studies that eldepryl hydrochloride tablets have any beneficial effect in the absence of concurrent levodopa therapy.

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This medication may interfere with certain medical/laboratory testsincluding brain scan for Parkinson’s diseasepossibly causing false test resultsMake sure laboratory personnel and all your doctors know you use this drug.

No pharmacokinetic information is available on selegiline or its metabolites in hepatically impaired subjects.

The selectivity of selegiline for MAO-B may not be absolute even at the recommended daily dose of 10 mg a dayRare cases of hypertensive reactions associated with ingestion of tyramine-containing foods have been reported in patients taking the recommended daily dose of selegilineThe selectivity is further diminished with increasing daily dosesThe precise dose at which selegiline becomes a non-selective inhibitor of all MAO is unknownbut may be in the range of 30 to 40 mg a day.

Since selegiline potentiates the effects of levodopathe adverse effects of levodopa may be increasedWhen selegiline is added to the maximum tolerated dose of levodopainvoluntary movements and agitation may occurLevodopa should be reduced by about 10 to 30when selegiline is added to the treatmentsee section 4.2 Posology and Method of AdministrationWhen an optimum dose of levodopa is reachedadverse effects from the combination are less than those observed with levodopa on its own.

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