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I attempted to contact the company that makes DiabetaSanofi-Aventisregarding the exact reason why the medication is not rated as equivalent to other glyburide productsHoweverthey could not give me the exact reasonThey said it is an older drug from 1984 that they inherited from another pharmaceutical companyHoechst.
YesGeneric glyburide can be substituted for Micronasethey are equivalentThe exception would be micronized glyburidewhich is equivalent to Glynase instead.
It may be harder to control your blood sugar when your body is stressedsuch as due to feverinfectioninjuryor surgeryConsult your doctor because this may require a change in your treatment planmedicationsor blood sugar testing.
When these measures fail to control the elevated blood sugaroral medications are usedIf oral medications are still insufficientinsulin medications are considered.
In a single-dose interaction study in NIDDM subjectsdecreases in glyburide AUC and Cmax were observedbut were highly variableThe single-dose nature of this study and the lack of correlation between glyburide blood levels and pharmacodynamic effectsmakes the clinical significance of this interaction uncertainCoadministration of glyburide and metformin did not result in any changes in either metformin pharmacokinetics or pharmacodynamics.
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