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Oral doses of Rocaltrolcalcitriolranging from 10 to 55 ng/kg/day have been shown to improve calcium homeostasis and bone disease in pediatric patients with chronic renal failure for whom hemodialysis is not yet requiredpredialysisLong-term calcitriol therapy is well tolerated by pediatric patientsThe most common safety issues are mildtransient episodes of hypercalcemiahyperphosphatemiaand increases in the serum calcium times phosphateCa x Pproduct which are managed effectively by dosage adjustment or temporary discontinuation of the vitamin D derivative.

Cholestyramine has been reported to reduce intestinal absorption of fat-soluble vitaminsas such it may impair intestinal absorption of Rocaltrolsee WARNINGS and PRECAUTIONSGeneral

Patients with normal or only slightly reduced serum calcium levels may respond to Rocaltrolcalcitrioldoses of 0.25 mcg every other dayMost patients undergoing hemodialysis respond to doses between 0.5 and 1 mcg/day.

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