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Laboratory FindingsIsolated instances of overdosage have included leukocytosisreduced leukocyte countglycosuriaand acetonuriaEEG may show dysrhythmias.

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Substantial evidence of Tegretol’s effectiveness for use in the management of children with epilepsysee INDICATIONS AND USAGE for specific seizure typesis derived from clinical investigations performed in adults and from studies in several in vitro systems which support the conclusion that1the pathogenetic mechanisms underlying seizure propagation are essentially identical in adults and childrenand2the mechanism of action of carbamazepine in treating seizures is essentially identical in adults and children.

Carbamazepine mustthereforebe considered to be carcinogenic in Sprague-Dawley ratsBacterial and mammalian mutagenicity studies using carbamazepine produced negative resultsThe significance of these findings relative to the use of carbamazepine in humans isat presentunknown.

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