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Investigations into the mode of action of LASIX have utilized micropuncture studies in ratsstop flow experiments in dogs and various clearance studies in both humans and experimental animalsIt has been demonstrated that LASIX inhibits primarily the absorption of sodium and chloride not only in the proximal and distal tubules but also in the loop of HenleThe high degree of efficacy is largely due to the unique site of actionThe action on the distal tubule is independent of any inhibitory effect on carbonic anhydrase and aldosterone.

Edema associated with congestive heart failureCHFliver cirrhosisand renal diseaseincluding nephrotic syndrome.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Pregnancy Category CFurosemide has been shown to cause unexplained maternal deaths and abortions in rabbits at 24 and 8 times the maximal recommended human doseThere are no adequate and well-controlled studies in pregnant womenLASIX should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

All patients receiving LASIX therapy should be observed for these signs or symptoms of fluid or electrolyte imbalancehyponatremiahypochloremic alkalosishypokalemiahypomagnesemia or hypocalcemiadryness of mouththirstweaknesslethargydrowsinessrestlessnessmuscle pains or crampsmuscular fatiguehypotensionoliguriatachycardiaarrhythmiaor gastrointestinal disturbances such as nausea and vomitingIncreases in blood glucose and alterations in glucose tolerance testswith abnormalities of the fasting and 2-hour postprandial sugarhave been observedand rarelyprecipitation of diabetes mellitus has been reported.

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