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What are the commonoccur in 30or more of patientsside effects of treatment with prednisone?

The initial dosage of DELTASONE Tablets may vary from 5 mg to 60 mg of prednisone per day depending on the specific disease entity being treatedIn situations of less severity lower doses will generally suffice while in selected patients higher initial doses may be requiredThe initial dosage should be maintained or adjusted until a satisfactory response is notedIf after a reasonable period of time there is a lack of satisfactory clinical responseDELTASONE should be discontinued and the patient transferred to other appropriate therapyIT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENTAfter a favorable response is notedthe proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reachedIt should be kept in mind that constant monitoring is needed in regard to drug dosageIncluded in the situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease processthe patient’s individual drug responsivenessand the effect of patient exposure to stressful situations not directly related to the disease entity under treatmentin this latter situation it may be necessary to increase the dosage of DELTASONE for a period of time consistent with the patient’s conditionIf after long-term therapy the drug is to be stoppedit is recommended that it be withdrawn gradually rather than abruptly.

Amphotericin BAmbisome and Amphotecpotassium depleting diuretics such as acetazolamideDiamoxand methazolamideNeptazaneanticholinesterases such as neostigmineProstigminand pyridostigmineMestinonwarfarinCoumadinmedications to treat diabetes isoniazid bupropionZyban and WellbutrincholestyraminePrevalitecyclosporineNeoralSandimmuneGengrafdigoxinLanoxinestrogens and oral contraceptives fluoroquinolone antibiotics such as ciprofloxacinCiproand levofloxacinLevaquinbarbituates such as phenobarbitalDonnatalphenytoinDilantincarbamazepineTegretolCarbatrolEquetroTerilEpitolrifampinRifadinRimactaneritonavirNorvirindinavirCrixivanmacrolide antibiotics such as erythromycin and azithromycinZithromaxnon-steroidal anti-inflammatory drugsNSAIDssuch as ibuprofenAdviland aspirinEcotrinquetiapineSeroquelthalidomideThalomidvaccines.

Take prednisone exactly as prescribedThis medication comes in tablet and oral solution forms and is usually taken one to four times a day or every other daywith food or milkIf prednisone upsets your stomachyou should take the medication along with food or milkIf you miss a doseconsult your doctor or pharmacist to determine the appropriate course of treatmentDo not take two doses of prednisone at the same time.

7In using ADT it is importantas in all therapeutic situations to individualize and tailor the therapy to each patientComplete control of symptoms will not be possible in all patientsAn explanation of the benefits of ADT will help the patient to understand and tolerate the possible flare-up in symptoms which may occur in the latter part of the off-steroid dayOther symptomatic therapy may be added or increased at this time if needed.

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