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Known hypersensitivitye.ganaphylactic reactions and serious skin reactionsto piroxicam or any components of the drug productsee WARNINGS AND PRECAUTIONSHistory of asthmaurticariaor other allergic-type reactions after taking aspirin or other NSAIDsSeveresometimes fatalanaphylactic reactions to NSAIDs have been reported in such patientssee WARNINGS AND PRECAUTIONSIn the setting of coronary artery bypass graftCABGsurgerysee WARNINGS AND PRECAUTIONS

NSAIDs may diminish the antihypertensive effect of angiotensin converting enzymeACEinhibitorsangiotensin receptor blockersARBsor beta-blockersincluding propranololIn patients who are elderlyvolume-depletedincluding those on diuretic therapyor have renal impairmentcoadministration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal functionincluding possible acute renal failureThese effects are usually reversible.

Elevations of ALT or ASTthree or more times the upper limit of normalULNhave been reported in approximately 1of NSAID-treated patients in clinical trialsIn additionraresometimes fatalcases of severe hepatic injuryincluding fulminant hepatitisliver necrosisand hepatic failure have been reported.

Talk to your doctor or pharmacist about the benefits and risks of taking this drug.

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