Lovastatin mevacor , pravastin pravachol , atorvastatin lipitor and simvastatine zocor are used to lower blood cholesterol levels by inhibiting the enzyme hmg coa reductase required to make cholesterol in the liver.
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49Krasovec MElsner PBurg GGeneralized eczematous skin rash possibly due to HMG-CoA reductase inhibitorsDermatology 1861993248-52.
10 years or olderInitial dose10 mg orally once a day in the evening Maintenance dose10 to 40 mg orally once a day in the evening Maximum dose40 mg orally once a day in the evening.
Simvastatin has been associated with rare cases of severe myopathy and rhabdomyolysisThis is accompanied by elevations in creatine kinasemyoglobinuriaand proteinuriaas well as renal failureExperience with HMG-CoA reductase inhibitors indicates that concomitant use with gemfibrozilnicotinic acidcyclosporinor erythromycin may increase the incidence and the severity of musculoskeletal side effects.
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