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Imuran is a slow onset drug, which means it may take 6-12 weeks for you to notice its effects.

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Cases of JC virus-associated infection resulting in progressive multifocal leukoencephalopathyPMLsometimes fatalhave been reported in patients treated with immunosuppressantsincluding ImuranRisk factors for PML include treatment with immunosuppressant therapies and impairment of immune functionConsider the diagnosis of PML in any patient presenting with new-onset neurological manifestations and consider consultation with a neurologist as clinically indicatedConsider reducing the amount of immunosuppression in patients who develop PMLIn transplant patientsconsider the risk that the reduced immunosuppression represents to the graft.

If you have an allergy to azathioprine or any other part of Imuranazathioprine tabletsIf you are allergic to any drugs like this oneany other drugsfoodsor other substancesTell your doctor about the allergy and what signs you hadlike rashhivesitchingshortness of breathwheezingcoughswelling of facelipstongueor throator any other signsIf you have ever been treated with chlorambucilcyclosporineor melphalan in the pastIf you are breast-feeding or plan to breast-feed.

Fevernight sweatsweight losstirednessfeeling full after eating only a small amountpain in your upper stomach that may spread to your shouldereasy bruising or bleedingpale skinfeeling light-headed or short of breathrapid heart rateor nausea.

Limited evidence suggests that Imuran is not beneficial to patients with hypoxanthine-guanine-phosphoribosyltransferase deficiencyLesch-Nyhan syndromeThereforegiven the abnormal metabolism in these patientsit is not prudent to recommend that these patients should receive Imuran.

Information is available on the risk of malignancy with the use of IMURAN in rheumatoid arthritissee ADVERSE REACTIONSIt has not been possible to define the precise risk of malignancy due to IMURANThe data suggest the risk may be elevated in patients with rheumatoid arthritisthough lower than for renal transplant patientsHoweveracute myelogenous leukemia as well as solid tumors have been reported in patients with rheumatoid arthritis who have received IMURAN.

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