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It is generally agreed that acute episodes of major depressive disorder require several months or longer of sustained pharmacological therapy beyond response to the acute episodeSystematic evaluation of continuing Lexapro 10 or 20 mg/day in adults patients with major depressive disorder who responded while taking Lexapro during an 8-weekacute-treatment phase demonstrated a benefit of such maintenance treatmentsee Clinical StudiesNeverthelessthe physician who elects to use Lexapro for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patientPatients should be periodically reassessed to determine the need for maintenance treatment.

Get medical help right away if you have any very serious side effectsincludingbloody/black/tarry stoolsfaintingfast/irregular heartbeatvomit that looks like coffee groundsseizureseye pain/swelling/rednesswidened pupilsvision changessuch as seeing rainbows around lights at nightblurred vision

A major depressive episode may be the initial presentation of bipolar disorderIt is generally believedthough not established in controlled trialsthat treating such an episode with an antidepressant alone may increase the likelihood of precipitation of a mixed/manic episode in patients at risk for bipolar disorderWhether any of the symptoms described above represent such a conversion is unknownHoweverprior to initiating treatment with an antidepressantpatients with depressive symptoms should be adequately screened to determine if they are at risk for bipolar disordersuch screening should include a detailed psychiatric historyincluding a family history of suicidebipolar disorderand depressionIt should be noted that Lexapro is not approved for use in treating bipolar depression.

This is not a complete list of side effects and others may occurCall your doctor for medical advice about side effectsYou may report side effects to FDA at 1-800-FDA-1088.

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