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Your blood sugar will need to be checked oftenand you may need other blood tests at your doctor’s office.

When transferring patients from insulin to glipizidethe following general guidelines should be consideredFor patients with daily insulin doses of 20 units or lessDiscontinue insulin and begin glipizide at usual dosagesFor patients with daily insulin doses greater than 20 unitsInsulin dose should be reduced by 50and glipizide therapy may begin at usual dosagesCommentsSeveral days should elapse between glipizide titration stepsSubsequent reductions in insulin dosage should depend on individual patient responseDuring the insulin withdrawal periodthe patient should test urine samples for sugar and ketone bodies at least three times dailySome patients receiving greater than 40 units of insulin daily may need to consider hospitalization during the transition period.

Neonates of women with gestational diabetes who are treated with sulfonylureas during pregnancy may be at increased risk for neonatal intensive care admission and may develop respiratory distresshypoglycemiabirth injuryand be large for gestational ageprolonged severe hypoglycemialasting 4-10 dayshas been reported in neonates born to mothers receiving a sulfonylurea at the time of delivery and has been reported with the use of agents with a prolonged half-lifeobserve newborns for symptoms of hypoglycemia and respiratory distress and manage accordingly.

Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drinkBe sure your family and close friends know how to give you this injection in an emergency.

This is not a complete list of side effects and others may occurCall your doctor for medical advice about side effectsYou may report side effects to FDA at 1-800-FDA-1088.

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