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Avoid taking a digestive enzyme such as pancreatinamylaseor lipase at the same time you take acarboseThese enzymes can make it harder for your body to absorb acarboseProducts that contain digestive enzymes include Arco-LaseCotazymDonnazymePancreaseCreonand Ku-Zyme.

In contrast to sulfonylureasPrecose does not enhance insulin secretionThe antihyperglycemic action of acarbose results from a competitivereversible inhibition of pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolase enzymesPancreatic alpha-amylase hydrolyzes complex starches to oligosaccharides in the lumen of the small intestinewhile the membrane-bound intestinal alpha-glucosidases hydrolyze oligosaccharidestrisaccharidesand disaccharides to glucose and other monosaccharides in the brush border of the small intestineIn diabetic patientsthis enzyme inhibition results in a delayed glucose absorption and a lowering of postprandial hyperglycemia.

The safety of Precose in pregnant women has not been establishedReproduction studies have been performed in rats at doses up to 480 mg/kgcorresponding to 9 times the exposure in humansbased on drug blood levelsand have revealed no evidence of impaired fertility or harm to the fetus due to acarboseIn rabbitsreduced maternal body weight gainprobably the result of the pharmacodynamic activity of high doses of acarbose in the intestinesmay have been responsible for a slight increase in the number of embryonic lossesHoweverrabbits given 160 mg/kg acarbosecorresponding to 10 times the dose in manbased on body surface areashowed no evidence of embryotoxicity and there was no evidence of teratogenicity at a dose 32 times the dose in manbased on body surface areaThere arehoweverno adequate and well-controlled studies of Precose in pregnant womenBecause animal reproduction studies are not always predictive of the human responsethis drug should be used during pregnancy only if clearly neededBecause current information strongly suggests that abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital anomalies as well as increased neonatal morbidity and mortalitymost experts recommend that insulin be used during pregnancy to maintain blood glucose levels as close to normal as possible.

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Acarbose does not usually cause low blood sugarhypoglycemiaLow blood sugar may occur if this drug is prescribed with other diabetes medicationsor if you do not consume enough calories from foodor if you do unusually heavy exerciseTalk with your doctor or pharmacist about whether the dose of your other diabetes medication(sneeds to be lowered.

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