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Your doctor may advise you to follow a special diet to help treat your condition.
The dosage of Zyloprim to accomplish full control of gout and to lower serum uric acid to normal or near-normal levels varies with the severity of the diseaseThe average is 200 to 300 mg/day for patients with mild gout and 400 to 600 mg/day for those with moderately severe tophaceous goutThe appropriate dosage may be administered in divided doses or as a single equivalent dose with the 300-mg tabletDosage requirements in excess of 300 mg should be administered in divided dosesThe minimal effective dosage is 100 to 200 mg daily and the maximal recommended dosage is 800 mg dailyTo reduce the possibility of flare-up of acute gouty attacksit is recommended that the patient start with a low dose of Zyloprim100 mg dailyand increase at weekly intervals by 100 mg until a serum uric acid level of 6 mg/dL or less is attained but without exceeding the maximal recommended dosage.
Zyloprim and its primary active metaboliteoxipurinolare eliminated by the kidneysthereforechanges in renal function have a profound effect on dosageIn patients with decreased renal function or who have concurrent illnesses which can affect renal function such as hypertension and diabetes mellitusperiodic laboratory parameters of renal functionparticularly BUN and serum creatinine or creatinine clearanceshould be performed and the patient’s dosage of Zyloprim reassessed.
Although most of the side effects listed below don’t happen very oftenthey could lead to serious problems if you do not seek medical attention.
Zyloprim can substantially reduce serum and urinary uric acid levels in previously refractory patients even in the presence of renal damage serious enough to render uricosuric drugs virtually ineffectiveSalicylates may be given conjointly for their antirheumatic effect without compromising the action of ZyloprimThis is in contrast to the nullifying effect of salicylates on uricosuric drugs.
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