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Information about Clozaril.

Patients in whom Clozaril has been discontinued as a result of either WBC or ANC deficienciessee abovemust not be re-exposed to Clozaril.

Since untreated mental/mood problemssuch as schizophreniaschizoaffective disorderscan be a serious conditiondo not stop taking this medication unless directed by your doctorIf you are planning pregnancybecome pregnantor think you may be pregnantimmediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

As a consequence of a recent European regulatory initiativethe Clozaril Summary of Product CharacteristicsSmPChas been harmonised across EuropeThe SmPC states that blood monitoring should be carried out in accordance with national-specific official recommendationsThese are reproduced below.

Prescribers are encouraged to keep a record of all patientsblood results and to take any steps necessary to prevent the patient being accidentally rechallenged in the future.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may affect the heart rhythmBefore using clozapinetell your doctor or pharmacist of all the drugs you take and if you have any of the following conditionscertain heart problemsheart failureslow heartbeatQT prolongation in the EKGfamily history of certain heart problemsQT prolongation in the EKGsudden cardiac death

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