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For nausea and vomiting in childrenthe usual dose is 0.5 mg per pound of body weightand the dose should be adjusted to the age and weight of the patient and the severity of the condition being treatedFor prophylaxis of nausea and vomitingas during surgery and the postoperative periodthe average dose is 25 mg repeated at 4to 6-hour intervalsas necessary.

Administration of promethazine HClpromethazine hydrochloridehas been associated with reported cholestatic jaundice.

Promethazine Hydrochloride Tablets USP50 mg also contain anhydrous lactose.

The average effective dose of promethazine hydrochloride for the active therapy of nausea and vomiting in children or adults is 25 mgWhen oral medication cannot be toleratedthe dose should be given parenterallycfPromethazine Injectionor by rectal suppository12.5to 25-mg doses may be repeatedas necessaryat 4-to 6-hour intervals.

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