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Caution is advised when using this drug in the elderly because they may be more sensitive to its effects.

An oral dose of 2 mg per kg daily for 8 to 12 weeksmaximum cumulative dose 168 mg per kgis recommendedTreatment beyond 90 days increases the probability of sterility in malessee Use in Specific Populations

If a patient has been treated with cyclophosphamide within 10 days of general anesthesiathe anesthesiologist should be alerted.

A very serious allergic reaction to this drug is unlikelybut seek immediate medical attention if it occursSymptoms of a serious allergic reaction may includerashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.

500 mg vial contains 534.5 mg cyclophosphamide monohydrate equivalent to 500 mg cyclophosphamide and 375 mg mannitol 1 g vial contains 1069.0 mg cyclophosphamide monohydrate equivalent to 1 g cyclophosphamide and 750 mg mannitol 2 g vial contains 2138.0 mg cyclophosphamide monohydrate equivalent to 2 g cyclophosphamide and 1500 mg mannitol.

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