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Duetact is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Colesevelam can decrease the absorption of glimepirideIf you are taking colesevelamtake this product at least 4 hours before taking colesevelam.

Pioglitazone may increase your risk of serious heart problemsHowevernot treating your diabetes can damage your heart and other organsTalk to your doctor about the risks and benefits of taking Duetact.

Pioglitazone hydrochloridea component of glimepiride/pioglitazone hydrochloridemay cause or exacerbate congestive heart failuremonitor patients for signs and symptoms of heart failure after initiation or dose increaseShould heart failure developmanage according to current standards of careConsider discontinuation or dose reductionGlimepiride/pioglitazone hydrochloride is not recommended in patients with symptomatic heart failure and is contraindicated in established NYHA Class III or IV heart failure

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