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The usual dose is 0.1 mg of Florinef Acetate dailyalthough dosage ranging from 0.1 mg three times a week to 0.2 mg daily has been employedIn the event transient hypertension develops as a consequence of therapythe dose should be reduced to 0.05 mg dailyFlorinef Acetate is preferably administered in conjunction with cortisone10 mg to 37.5 mg daily in divided dosesor hydrocortisone10 mg to 30 mg daily in divided doses

Prolonged use of corticosteroids may produce posterior subcapsular cataractsglaucoma with possible damage to the optic nervesand may enhance the establishment of secondary ocular infections due to fungi or viruses.

In larger dosesfludrocortisone acetate inhibits endogenous adrenal cortical secretionthymic activityand pituitary corticotropin excretionpromotes the deposition of liver glycogenandunless protein intake is adequateinduces negative nitrogen balance.

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