Caution should be exercised when the following drugs are administered concomitantly with sinemet cr.

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If general anesthesia is requiredSINEMET may be continued as long as the patient is permitted to take fluids and medication by mouthIf therapy is interrupted temporarilythe patient should be observed for symptoms resembling NMSand the usual daily dosage may be administered as soon as the patient is able to take oral medication.

PO Box 1147 Strawberry Hills NSW 2012 Level 7418A Elizabeth StSurry Hills NSW 2010 ABN61 082 034 393.

You have an allergy to SINEMET or any of the ingredients listed at the end of this leaflet you have any unusual skin lumps or moles which have not been examined by your doctoror if you have ever had skin cancer or melanoma you have a type of glaucoma called narrow-angle glaucoma are being treated for depression with certain medicines called monoamine oxidaseMAOinhibitors Ask your doctor or pharmacist if you are not sure whether you are taking one of these medicinesyou are breast-feeding or plan to breast-feed It has been shown that one of the active ingredients of SINEMET passes into breast milkThereforebecause of the potential harm to the babySINEMET should not be used during breast-feedingthe packaging is torn or shows signs of tampering the expiry date on the pack has passedIf you take this medicine after the expiry date has passedit may not work.

Pyridoxine hydrochloridevitamin B6in oral doses of 10 mg to 25 mgmay reverse the effects of levodopa by increasing the rate of aromatic amino acid decarboxylationCarbidopa inhibits this action of pyridoxinethereforeSINEMET can be given to patients receiving supplemental pyridoxinevitamin B 6

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