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COUMADIN is prescription medicine used to treat blood clots and to lower the chance of blood clots forming in your bodyBlood clots can cause a strokeheart attackor other serious conditions if they form in the legs or lungs.

Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficult breathingswelling of your facelipstongueor throat.

Clots formed by Coumadin may block normal blood flowwhich could lead to tissue death or amputation of the affected body partGet medical help at once if you have:

Frequency not reportedHypersensitivityallergic reactionsanaphylactic reactionsRef]

The terminal half-life of warfarin after a single dose is approximately 1 weekhoweverthe effective half-life ranges from 20 to 60 hourswith a mean of about 40 hoursThe clearance of R-warfarin is generally half that of S-warfarinthus as the volumes of distribution are similarthe half-life of Rwarfarin is longer than that of S-warfarinThe half-life of R-warfarin ranges from 37 to 89 hourswhile that of S-warfarin ranges from 21 to 43 hoursStudies with radiolabeled drug have demonstrated that up to 92of the orally administered dose is recovered in urineVery little warfarin is excreted unchanged in urineUrinary excretion is in the form of metabolites.

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