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Excessive diuresis may cause dehydration and blood volume reduction with circulatory collapse and possibly vascular thrombosis and embolismparticularly in elderly patients.
Furosemide caused unexplained maternal deaths and abortions in the rabbit at the lowest dose of 25 mg/kg2 times the maximal recommended human dose of 600 mg/dayIn another studya dose of 50 mg/kg4 times the maximal recommended human dose of 600 mg/dayalso caused maternal deaths and abortions when administered to rabbits between Days 12 and 17 of gestationIn a third studynone of the pregnant rabbits survived a dose of 100 mg/kgData from the above studies indicate fetal lethality that can precede maternal deaths.
In patients with severe symptoms of urinary retentionbecause of bladder emptying disordersprostatic hyperplasiaurethral narrowingthe administration of furosemide can cause acute urinary retention related to increased production and retention of urineThusthese patients require careful monitoringespecially during the initial stages of treatment.
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In fasted normal menthe mean bioavailability of furosemide from LASIX Tablets and LASIX Oral Solution is 64and 60respectivelyof that from an intravenous injection of the drugAlthough furosemide is more rapidly absorbed from the oral solution50 minutesthan from the tablet87 minutespeak plasma levels and area under the plasma concentration-time curves do not differ significantlyPeak plasma concentrations increase with increasing dose but times-topeak do not differ among dosesThe terminal half-life of furosemide is approximately 2 hours.
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