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When cyclophosphamide is included in combined cytotoxic regimensit may be necessary to reduce the dose of cyclophosphamide as well as that of the other drugs.

Cytoxanalthough effective alone in susceptible malignanciesis more frequently used concurrently or sequentially with other antineoplastic drugsThe following malignancies are often susceptible to Cytoxan treatment:

Leukopenia Thrombocytopenia Tumor cell infiltration of bone marrow Previous X-ray therapy Previous therapy with other cytotoxic agents Impaired hepatic function Impaired renal function.

Cyclophosphamide may lessen the chance of having children in both men and womenSterility is usually temporary with this medicationbut can be permanent in some casesConsult your doctor for more details.

If not used immediatelyfor microbiological integritycyclophosphamide solutions should be stored as described in Table 3:

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