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Information about Colchicine.
Colchicine is also available in capsulesThe capsules are available as the brand-name drug MitigareThe capsules are also available as generic drugs.
Four pharmacokinetic studies evaluated the effects of co-administration of voriconazole200 mg BIDfluconazole200 mg QDcimetidine800 mg BIDand propafenone225 mg BIDon systemic levels of colchicineColchicine can be administered with these drugs at the tested doses without a need for dose adjustmentHoweverthese results should not be extrapolated to other co-administered drugsSee CYP3A4P-Glycoprotein and Pharmacokinetics
Co-administration of colchicine capsules with propafenonea P-gp inhibitorat 225 mg BID for 5 daysin a pharmacokinetic study in healthy volunteersdid not cause any changes in systemic levels of colchicineThis indicates that propafenone can be administered with colchicine capsules without any dose adjustmentHoweverthese results should not be extrapolated to other P-gp inhibitors as colchicine is known to be a substrate for P-gp and case reports of colchicine toxicity associated with the co-administration of P-gp inhibitors such as cyclosporine have been published.
DisclaimerOur goal is to provide you with the most relevant and current informationHoweverbecause drugs interact differently in each personwe cannot guarantee that this information includes all possible interactionsThis information is not a substitute for medical adviceAlways speak with your healthcare provider about possible interactions with all prescription drugsvitaminsherbs and supplementsand over-the-counter drugs that you are taking.
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