Cytotec may be taken vaginally, rectally, placed between the cheek and gum buccally , sublingually placed underneath the tongue and swallowed.

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Cytotec is not fetotoxic or teratogenic in rats and rabbits at doses 625 and 63 times the human doserespectively.

Cytotec should be taken only according to the directions given by a physician.

Gastrointestinal bleedingulcerationand perforation have occurred in NSAID-treated patients receiving misoprostolPhysicians and patients should remain alert for ulcerationeven in the absence of gastrointestinal symptomsandwhere appropriateendoscopy and biopsy should be carried out before use to ensure that malignant disease is absent in the upper gastrointestinal tractThese investigations and any others considered necessary by the clinician should be repeated at appropriate intervals for follow-up purposes.

The toxic dose of Cytotec in humans has not been determinedCumulative total daily doses of 1600 mcg have been toleratedwith only symptoms of gastrointestinal discomfort being reportedIn animalsthe acute toxic effects are diarrheagastrointestinal lesionsfocal cardiac necrosishepatic necrosisrenal tubular necrosistesticular atrophyrespiratory difficultiesand depression of the central nervous systemClinical signs that may indicate an overdose are sedationtremorconvulsionsdyspneaabdominal paindiarrheafeverpalpitationshypotensionor bradycardiaSymptoms should be treated with supportive therapy.

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