Synthroid levothyroxine is a replacement for a hormone that is normally produced by your thyroid gland to regulate the body s energy and metabolism.

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Hair loss may happen in some people in the first few months of using Synthroidlevothyroxine tabletsThis most often goes back to normal.

You may not be able to take Synthroid if you have certain medical conditionsTell your doctor if you have an untreated or uncontrolled adrenal gland disordera thyroid disorder called thyrotoxicosisor if you have any recent or current symptoms of a heart attack.

Headachesleep problemsinsomniafeeling nervous or irritablefeverhot flashessweatingpounding heartbeats or fluttering in your chestchanges in your menstrual periodsor appetite changesweight changes.

Absorption of orally administered T 4 from the gastrointestinalGItract ranges from 40to 80The majority of the levothyroxine dose is absorbed from the jejunum and upper ileumThe relative bioavailability of SYNTHROID tabletscompared to an equal nominal dose of oral levothyroxine sodium solutionis approximately 93T 4 absorption is increased by fastingand decreased in malabsorption syndromes and by certain foods such as soybean infant formulaDietary fiber decreases bioavailability of T 4Absorption may also decrease with ageIn additionmany drugs and foods affect T 4 absorptionsee DRUG INTERACTIONS and Drug-Food Interactions

The recommended frequency of monitoring of TSH and total or free T 4 in children is as followsat 2 and 4 weeks after the initiation of treatmentevery 1-2 months during the first year of lifeevery 2-3 months between 1 and 3 years of ageand every 3 to 12 months thereafter until growth is completedMore frequent intervals of monitoring may be necessary if poor compliance is suspected or abnormal values are obtainedIt is recommended that TSH and T 4 levelsand a physical examinationif indicatedbe performed 2 weeks after any change in SYNTHROID dosageRoutine clinical examinationincluding assessment of mental and physical growth and developmentand bone maturationshould be performed at regular intervalssee PRECAUTIONSPediatric Use and DOSAGE AND ADMINISTRATION

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