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23Barrett-Connor EBush TLEstrogen and coronary heart disease in womenJAMA 26519911861-7.

Tendernessenlargementpainnipple dischargegalactorrheafibrocystic breast changesbreast cancer.

The distribution of exogenous estrogens is similar to that of endogenous estrogensEstrogens are widely distributed in the body and are generally found in higher concentrations in the sex hormone target organsEstrogens circulate in the blood largely bound to sex hormone binding globulinSHBGand albumin.

Treatment is usually initiated with a dose of 1 to 2 mg daily of estradioladjusted as necessary to control presenting symptomsthe minimal effective dose for maintenance therapy should be determined by titration.

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