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Before taking mefenamic acidtell your doctor if you are taking any of the following drugs:

Following a single 1-gram oral dosemean peak plasma levels ranging from 10-20 mcg/mL have been reportedPeak plasma levels are attained in 2 to 4 hours and the elimination half-life approximates 2 hoursFollowing multiple dosesplasma levels are proportional to dose with no evidence of drug accumulationIn a multiple dose trial of normal adult subjectsn=6receiving 1-gram doses of mefenamic acid four times dailysteady-state concentrations of 20 mcg/mL were reached on the second day of administrationconsistent with the short half-life.

Strategies to Minimize the GI Risks in NSAID-treated patients Use the lowest effective dosage for the shortest possible durationAvoid administration of more than one NSAID at a timeAvoid use in patients at higher risk unless benefits are expected to outweigh the increased risk of bleedingFor such patientsas well as those with active GI bleedingconsider alternate therapies other than NSAIDsRemain alert for signs and symptoms of GI ulceration and bleeding during NSAID therapyIf a serious GI adverse event is suspectedpromptly initiate evaluation and treatmentand discontinue Ponstel until a serious GI adverse event is ruled outIn the setting of concomitant use of low-dose aspirin for cardiac prophylaxismonitor patients more closely for evidence of GI bleedingsee PRECAUTIONSDrug Interactions

This is not a list of all drugs or health problems that interact with Ponstelmefenamic acid

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