The patient was treated successively with azithromycin, roxithromycin and minocycline hydrochloride, but there was no improvement.

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Antacids containing aluminumcalciummagnesium and iron-containing medications can bind with minocyclinedelay the absorptionand reduce the effectiveness of minocycline.

Children 8 years of age and olderimmediate-release tablets and capsulesThe recommended dose of minocycline is4 mg/kg initiallyfollowed by 2 mg/kg every 12 hoursnot to exceed the usual adult dose.

Minocycline should be used with caution with anticoagulant medications such as warfarinCoumadinbecause it increases the risk of bleeding and bruising.

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