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Patients receiving a phosphodiesterase type 5PDE5inhibitorsildenafiltadalafilor vardenafilshould be advised that they may be at an increased risk of PDE5 inhibitor-associated adverse events including hypotensionvisual changesand priapismand should promptly report any symptoms to their doctorssee CONTRAINDICATIONS and WARNINGSDRUG INTERACTIONS

For many people with HIVthe use of ART has increased their CD4cell counts and decreased the amount of HIV in their bloodviral loadThese beneficial effects help to reduce the risk of developing a life-threatening infectionNeither indinavir nor any other anti-HIV medication is a cure for HIVIt is therefore important that you do the following:

For optimal absorptionCRIXIVAN should be administered without food but with water 1 hour before or 2 hours after a mealAlternativelyCRIXIVAN may be administered with other liquids such as skim milkjuicecoffeeor teaor with a light meale.gdry toast with jellyjuiceand coffee with skim milk and sugaror corn flakesskim milk and sugarsee CLINICAL PHARMACOLOGYEffect of Food on Oral Absorption and DOSAGE AND ADMINISTRATIONIngestion of CRIXIVAN with a meal high in caloriesfatand protein reduces the absorption of indinavir.

Of courseif you have persistent diarrhea or vomitingyou should contact your doctor.

Tell your doctor and pharmacist if you are allergic to indinavirany other medicationsor any of the ingredients in indinavir capsulesAsk your pharmacist for a list of the ingredientstell your doctor if you are taking any of the following medicationsalfuzosinUroxatralalprazolamXanaxamiodaroneCordaroneNexteronePaceronecisapridePropulsidnot available in the U.Sergot-type medications such as dihydroergotamineD.H.E45MigranalergonovineErgotrateergotamineErgomarin Cafergotin Migergotand methylergonovineMetherginelovastatinAltoprevMevacorlurasidoneLatudamidazolamVersedby mouthpimozideOrapsildenafilonly Revatio brand used for lung diseasesimvastatinZocorin Vytorinor triazolamHalcionYour doctor will probably tell you not to take indinavirtell your doctor and pharmacist what other prescription and nonprescription medicationsvitaminsand nutritional supplements you are taking or plan to takeBe sure to mention any of the followingbosentanTracleercalcium-channel blockers such as amlodipineNorvascin Amturnidein Tekamlofelodipinenicardipineand nifedipineAdalatAfeditabProcardiacarbamazepineCarbatrolEpitolEquetroTegretolotherscholesterol-lowering medicationsstatinssuch as atorvastatinLipitorin Caduetand rosuvastatinCrestorclarithromycinBiaxinin PrevPaccolchicineColcrysMitigarein Col-ProbeneciddexamethasonefluconazoleDiflucanfluticasoneFlonaseFloventin Advairin DymistaitraconazoleOnmelSporanoxketoconazoleExtinaNizoralXolegelother medications for HIV including atazanavirReyatazin EvotazdelavirdineRescriptorefavirenzSustivain AtriplanelfinavirViraceptnevirapineViramuneritonavirNorvirin Kaletrain Viekira Pakand saquinavirInvirasemedications for irregular heartbeat such as lidocaineGlydoXylocaineand quinidinein Nuedextamedications that suppress the immune system such as cyclosporineGengrafNeoralSandimmunesirolimusRapamuneand tacrolimusAstagraf XLEnvarsus XRPrografmidazolamVersedby injectioncertain phosphodiesterase inhibitorsPDE-5 inhibitorsused for erectile dysfunction such as sildenafilViagratadalafilAdcircaCialisand vardenafilLevitrain StaxynphenobarbitalphenytoinDilantinPhenytekquetiapineSeroquelrifabutinMycobutinrifampinRifadinRimactanein Rifamatein RifatersalmeterolSereventin Advairtrazodoneand venlafaxineEffexorYour doctor may need to change the doses of your medications or monitor you carefully for side effectsMany other medications may also interact with indinavirso be sure to tell your doctor about all the medications you are takingeven those that do not appear on this listtell your doctor what herbal products you are takingespecially StJohn’s wortif you are taking didanosineVidextake it at least one hour before or after indinavirtell your doctor if you have or have ever had hemophiliableeding disorder in which the blood does not clot properlydiabetesor kidney or liver diseasetell your doctor if you are pregnantplan to become pregnantor are breastfeedingIf you become pregnant while taking indinavircall your doctorYou should not breastfeed if you are infected with HIV or if you are taking indinaviryou should know that your body fat may increase or move to different areas of your body such as your breastsupper backneckchestand stomach areaLoss of fat from the legsarmsand face can also happenyou should know that you may experience hyperglycemiaincreases in your blood sugarwhile you are taking this medicationeven if you do not already have diabetesTell your doctor immediately if you have any of the following symptoms while you are taking indinavirextreme thirstfrequent urinationextreme hungerblurred visionor weaknessIt is very important to call your doctor as soon as you have any of these symptomsbecause high blood sugar that is not treated can cause a serious condition called ketoacidosisKetoacidosis may become life-threatening if it is not treated at an early stageSymptoms of ketoacidosis include dry mouthnausea and vomitingshortness of breathbreath that smells fruityand decreased consciousnessyou should know that while you are taking medications to treat HIV infectionyour immune system may get stronger and begin to fight other infections that were already in your bodyThis may cause you to develop symptoms of those infectionsIf you have new or worsening symptoms at anytime during your treatment with indinavirbe sure to tell your doctor.

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