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AffiliationsDepartment of Epidemiology and BiostatisticsImperial College LondonLondonUnited KingdomInstitute of Health SciencesUniversity of OuluOuluFinlandBiocenter OuluUniversity of OuluOuluFinlandUnit of Primary CareOulu University HospitalOuluFinlandDepartment of Children and Young People and FamiliesNational Institute for Health and WelfareOuluFinland.

For the replicated SNP in the SAPALDIA replication armas well as for the lung function analysisa two-sided p-value of 0.05 was considered significantWe investigated heterogeneity between asthmatics and non-asthmatics in the discovery arm by testing for a difference between the two effectsusing a chi-square test with one degree of freedom.

Characteristics of study populations contributing to the SNP association analyses with FEV1.

We present here an agnostic investigation of genetic determinants of circulating AAT levels in a general population sample by performing a genome-wide association studyGWASin 1392 individuals of the SAPALDIA cohort.

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