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Both in vitro and in vivo studies have shown that clindamycin reduces the production of exotoxins by staphylococci, 17 it may also induce changes in the surface structure of bacteria that make them more sensitive to immune system attack opsonization and phagocytosis .

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What to do if you miss a doseTake your dose as soon as you rememberBut if you remember just a few hours before your next scheduled dosetake only one doseNever try to catch up by taking two doses at onceThis could result in dangerous side effects.

Hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the serum.

Clindamycin can cause diarrheawhich may be severe or lead to seriouslife-threatening intestinal problemsIf you have diarrhea that is watery or bloodystop using this medicine and call your doctor.

Prescribing CLEOCIN HCl in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

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