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Rheumatoid arthritisThe usual adult starting dose is 400 mg to 600 mg dailyIt may take several weeks before the beneficial effects of hydroxychloroquine for the treatment of rheumatoid arthritis are seenand several months before maximum effects are achievedAfter 5 to 10 daysthe dose may be gradually increasedAfter a good response to treatment is seenusually within 4 to 12 weeksthe dose is decreased to 200 mg to 400 mg daily.

The risk of retinal damage is small with daily doses of up to 6.5 mg/kg body weightExceeding the recommended daily dose sharply increases the risk of retinal toxicityThis examination should be more frequent and adapted to the patient in the following situations:

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