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Uncommon0.1to 1Decreased bone mineral densityosteopeniaosteoporosis and fractures on long term therapy.

Very common10or moreAbdominal paindiarrheadyspepsiagingival disordernauseavomiting.

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Serious liver damage that can cause deathespecially in children younger than 2 years oldThe risk of getting this serious liver damage is more likely to happen within the first 6 months of treatmentIn some casesliver damage may continue despite stopping the drugCall your healthcare provider right away if you get any of the following symptomsnausea or vomiting that does not go awayloss of appetitepain on the right side of your stomachabdomendark urineswelling of your faceor yellowing of your skin or the whites of your eyesDepakote may harm your unborn babyIf you take Depakote during pregnancy for any medical conditionyour baby is at risk for serious birth defects that affect the brain and spinal cord and are called spina bifida or neural tube defectsThese defects occur in 1 to 2 out of every 100 babies born to mothers who use this medicine during pregnancyThese defects can begin in the first montheven before you know you are pregnantOther birth defects that affect the structures of the heartheadarmslegsand the opening where the urine comes outurethraon the bottom of the penis can also happenBirth defects may occur even in children born to women who are not taking any medicines and do not have other risk factorsTaking folic acid supplements before getting pregnant and during early pregnancy can lower the chance of having a baby with a neural tube defectIf you take Depakote during pregnancy for any medical conditionyour child is at risk for having a lower IQThere may be other medicines to treat your condition that have a lower chance of causing birth defects and decreased IQ in your childWomen who are pregnant must not take Depakote to prevent migraine headachesAll women of childbearing age should talk to their healthcare provider about using other possible treatments instead of DepakoteIf the decision is made to use Depakoteyou should use effective birth controlcontraceptionTell your healthcare provider right away if you become pregnant while taking DepakoteYou and your healthcare provider should decide if you will continue to take Depakote while you are pregnantPregnancy RegistryIf you become pregnant while taking Depakotetalk to your healthcare provider about registering with the North American Antiepileptic Drug Pregnancy RegistryYou can enroll in this registry by calling 1-888-233-2334The purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancyInflammation of your pancreas that can cause deathCall your healthcare provider right away if you have any of these symptomssevere stomach pain that you may also feel in your backnausea or vomiting that does not go awayLike other antiepileptic drugsDepakote may cause suicidal thoughts or actions in a very small number of peopleabout 1 in 500Call a healthcare provider right away if you have any of these symptomsespecially if they are newworseor worry youthoughts about suicide or dyingattempts to commit suicidenew or worse depressionnew or worse anxietyfeeling agitated or restlesspanic attackstrouble sleepinginsomnianew or worse irritabilityacting aggressivebeing angryor violentacting on dangerous impulsesan extreme increase in activity and talkingmaniaother unusual changes in behavior or moodHow can I watch for early symptoms of suicidal thoughts and actionsPay attention to any changesespecially sudden changes in moodbehaviorsthoughtsor feelingsKeep all follow-up visits with your healthcare provider as scheduledCall your healthcare provider between visits as neededespecially if you are worried about symptoms.

Frequency not reportedAngioedemageneralized pruritusphotosensitivityRef]

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