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The second trial was conducted in 34 additional pediatric patients with newly diagnosed nondisseminated intrinsic diffuse brainstem gliomasmedian age 7 yearsrange 3-16 yearsand 10 pediatric patients who received the MTD of capecitabine in the dose-finding trial and met the eligibility criteria for this trialAll patients received 650 mg/m 2 capecitabine every 12 hours with concomitant radiation therapy for up to 9 weeksAfter a 2 week breakpatients received 1250 mg/m 2 capecitabine every 12 hours on Days 1-14 of a 21-day cycle for up to 3 cycles.

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